Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Computed Tomography01:10

Computed Tomography

9.5K
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
9.5K
Assessment of Diffusion and Perfusion01:17

Assessment of Diffusion and Perfusion

2.0K
Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this...
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Placement of Endovascular Stent for Reperfusion of Cerebral Infarct After Pediatric Traumatic Internal Carotid Artery Dissection.

Journal of radiology case reports·2024
Same author

The Role of Vertebral Augmentation Procedures in the Management of Multiple Myeloma.

Clinical hematology international·2024
Same author

Ischemia of the parotid gland and adjacent muscles of mastication following middle meningeal artery embolization.

The neuroradiology journal·2023
Same author

Bilateral Carotid-Cavernous Fistula: A Diagnostic and Therapeutic Challenge.

Journal of investigative medicine high impact case reports·2022
Same author

Mechanical thrombectomy through a 'carotid-carotid bypass'.

BMJ case reports·2021
Same author

Continued Underutilization of stroke care during the COVID-19 pandemic.

Brain, behavior, & immunity - health·2021

Related Experiment Video

Updated: Mar 27, 2026

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
11:09

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

Published on: December 16, 2022

4.5K

Time density curve analysis for C-arm FDCT PBV imaging.

Mudassar Kamran1, James V Byrne2

  • 1Nuffield Department of Surgical Sciences, University of Oxford, UK m.kamran@oxon.org.

Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences
|January 16, 2016
PubMed
Summary

Parenchymal blood volume (PBV) estimation using C-arm CT requires a steady-state contrast concentration, but this study found significant variations in contrast dynamics across patients. Achieving a closer approximation to the steady-state improves the agreement of PBV measurements with MR-CBV.

Keywords:
C-arm flat detector computed tomographyMR perfusion-weighted imagingParenchymal blood volumecerebral blood volumetime density curve

More Related Videos

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function
10:21

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function

Published on: August 8, 2019

8.9K
Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling
12:29

Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling

Published on: May 30, 2011

14.3K

Related Experiment Videos

Last Updated: Mar 27, 2026

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
11:09

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

Published on: December 16, 2022

4.5K
Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function
10:21

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function

Published on: August 8, 2019

8.9K
Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling
12:29

Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling

Published on: May 30, 2011

14.3K

Area of Science:

  • Neuroradiology
  • Medical Imaging Physics

Background:

  • C-arm flat detector computed tomography (FDCT) is used for parenchymal blood volume (PBV) estimation.
  • This estimation relies on the assumption of a steady-state contrast concentration in cerebral vasculature during the scan.
  • Variability in contrast-material dynamics across patients may impact the accuracy of PBV measurements.

Purpose of the Study:

  • To investigate if the steady-state assumption is met in C-arm CT PBV scans.
  • To assess the consistency of contrast-material dynamics in cerebral vasculature among patients.
  • To determine the influence of contrast dynamics on PBV measurement agreement with MR-CBV.

Main Methods:

  • Analysis of 30 C-arm FDCT datasets from 26 patients with aneurysmal subarachnoid hemorrhage.
  • Extraction of time density curves (TDCs) from 2D rotational projections.
  • Testing goodness-of-fit to a steady-state model and statistical similarity among TDCs; calculation of the influence of TDC characteristics on PBV agreement with MR-CBV.

Main Results:

  • Individual TDCs were statistically non-identical across patients, with 62% showing significant differences (p < 0.01).
  • All TDCs significantly deviated from the steady-state horizontal-line-model (p < 0.01).
  • PBV measurements with TDCs deviating most from steady-state showed poorer agreement and correlation with MR-CBV.

Conclusions:

  • The 'ideal steady-state' contrast concentration is not achieved during clinical C-arm CT PBV examinations.
  • The degree to which TDCs approximate the ideal steady-state influences the agreement of PBV measurements with MR-CBV.
  • Optimizing contrast injection protocols may enhance the accuracy of C-arm CT PBV estimations.