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Thyroid Function, Prevalent Coronary Heart Disease, and Severity of Coronary Atherosclerosis in Patients Undergoing

Yan Ling1, Jingjing Jiang1, Minghui Gui1

  • 1Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai 200032, China.

International Journal of Endocrinology
|January 16, 2016
PubMed

Insights

Thyroid function impacts coronary heart disease (CHD) and its severity. Lower free T4 levels and hypothyroidism are linked to prevalent CHD and more severe atherosclerosis in patients undergoing angiography.

Area of Science:

  • Cardiology
  • Endocrinology
  • Thyroidology

Background:

  • Thyroid dysfunction is common and linked to cardiovascular disease.
  • The relationship between thyroid function and coronary atherosclerosis severity requires further investigation.

Purpose of the Study:

  • To investigate the association between thyroid function (free T4, TSH, and categories) and prevalent coronary heart disease (CHD).
  • To assess the relationship between thyroid function and the severity of coronary atherosclerosis.

Main Methods:

  • Cross-sectional study of 1799 patients undergoing coronary angiography.
  • Thyroid function categories (euthyroid, hyperthyroidism, hypothyroidism) and free T4 levels were assessed.
  • Coronary atherosclerosis severity was quantified using the Gensini score.

Main Results:

  • Free T4 levels were inversely associated with prevalent CHD and Gensini score.
  • Hypothyroidism, particularly overt hypothyroidism, was linked to increased odds of CHD and higher atherosclerosis severity.
  • These associations were not significant in euthyroid individuals.

Conclusions:

  • Thyroid function is associated with prevalent CHD and coronary atherosclerosis severity in patients undergoing angiography.
  • Hypothyroidism may contribute to the development and progression of coronary artery disease.
  • Further research is needed to clarify the role of thyroid function in cardiovascular health, especially in euthyroid individuals.

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