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Association between sodium iodide symporter and differentiated Thyroid cancer: a meta-analysis of 9 studies
Rui Zhang1, Huanjun Wang1, Junyu Zhao1
1Department of Internal Medicine, Division of Endocrinology, Shandong Provincial Qian Foshan Hospital Jinan 250014, China.
Context:
As many studies proved that sodium iodide symporter (NIS) plays a key role in radioactive iodide (RAI) therapy of thyroid cancer, however, a growing number of studies suggests that part of differentiated thyroid carcinomas (DTC) with overexpression of NIS are insensitive to RAI well.
Objective:
The aim of this meta-analysis is to assess the expression of NIS in differentiated thyroid cancer, compared with normal thyroid tissue.
Data Sources:
PUBMED, Sinomed, CNKI, Wanfang and VIP were searched for relevant case-control studies up to now.
Study Selection:
Studies that concerning the qualitative expression NIS in DTC were included.
Data Extraction:
Working independently, authors used a standard form to extract data. For quality assessment, Newcastle-Ottawa Scale (NOS) were applied.
Data Synthesis:
Totally nine eligible studies included, involving 765 cases and 473 controls. The results revealed that the expression of NIS had a statistically increased in DTC, compared with controls (OddsRadio OR: 1.47, 95% CI: 1.12 to 1.94, Z=2.78, P=0.005). Since the existence of the significant heterogeneity, subgroup analysis and sensitivity analysis were performed and found that the heterogeneity came from the different criteria evaluate positive NIS expression (Liu 2008, Mu 2010) and the small simple size of the control group (Lin. J D2001). The heterogeneity disappeared or dropped to below 50% after remove these studies.
Conclusion:
Our study shows that the expression of NIS is significantly increased in DTC, which could help explain the reason for individual with a poor response to RAI therapy. In other word, the reduced iodide uptake in thyroid cancer may not caused by the decreased expression of NIS, function of NIS protein or its post-transcriptional translocation might be the point.
Insights
The sodium iodide symporter (NIS) is significantly increased in differentiated thyroid cancer (DTC). This finding may explain why some patients do not respond well to radioactive iodide (RAI) therapy, suggesting issues beyond expression levels.
Area of Science:
- Oncology
- Molecular Biology
- Radiotherapy
Background:
- The sodium iodide symporter (NIS) is crucial for radioactive iodide (RAI) therapy in thyroid cancer.
- However, some differentiated thyroid carcinomas (DTC) show resistance to RAI despite NIS overexpression.
Purpose of the Study:
- To conduct a meta-analysis assessing NIS expression in differentiated thyroid cancer (DTC) compared to normal thyroid tissue.
Main Methods:
- Searched major databases (PUBMED, Sinomed, CNKI, Wanfang, VIP) for relevant case-control studies.
- Included studies focused on qualitative NIS expression in DTC.
- Data extraction and quality assessment were performed using a standard form and the Newcastle-Ottawa Scale (NOS).
Main Results:
- Nine studies with 765 cases and 473 controls were included.
- NIS expression was statistically increased in DTC compared to controls (OR: 1.47, 95% CI: 1.12-1.94, P=0.005).
- Subgroup and sensitivity analyses identified heterogeneity due to differing positive NIS expression criteria and small control group sizes, which resolved upon their exclusion.
Conclusions:
- NIS expression is significantly elevated in DTC, potentially explaining poor response to RAI therapy.
- Reduced iodide uptake in thyroid cancer may not stem from decreased NIS expression alone.
- NIS protein function or post-transcriptional translocation could be critical factors in RAI therapy response.
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