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Updated: Mar 27, 2026
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Published on: March 19, 2016
Changes in platelet function following cold storage of RBC suspensions
Qian-Li Dang1, Jian-Gang Li2, Yang Sun1
1Department of Transfusion Medicine, The Third Affiliated Hospital of Medical College of Xi'an Jiaotong University Xi'an 710068, China.
Objective:
To provide a basis for the cold-storage of human platelets as a way to assess changes in platelet function.
Methods:
Red blood cell suspensions (11 U and 50 U) were randomly selected at different storage times (3-28 days) and evidence of platelet activation (CD62P) and thromboelastography (TEG) reaction times were investigated.
Results:
After 21 days of storage at 4°C, a large number of activated platelets (PAC1+62P+, PAC1-62P+) within the red blood cell suspension (RBCs) retained their function and had TEG-maximum amplitude (TEG-MA) indices in the normal range.
Conclusion:
We report that platelets in RBC suspensions retain high activity when stored at 4°C for 21 days. The results provide important information for studies that involve storing platelets under cold conditions.
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