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Association between left ventricular end-diastolic pressure and coronary artery disease as well as its extent and

Lai-Jing Du1, Ping-Shuan Dong1, Jing-Jing Jia1

  • 1Department of Cardiology, The First Affiliated Hospital of Henan Science and Technology University Luoyang 471003, China.

International Journal of Clinical and Experimental Medicine
|January 16, 2016
PubMed

Insights

Elevated left ventricular end-diastolic pressure (LVEDP) is linked to coronary artery disease (CAD). Higher LVEDP indicates more severe CAD, offering clinical value for both CAD and non-CAD patients.

Area of Science:

  • Cardiology
  • Cardiovascular Research
  • Diagnostic Medicine

Background:

  • Myocardial ischemia is associated with elevated left ventricular end-diastolic pressure (LVEDP).
  • Left ventricular end-diastolic pressure (LVEDP) is a key indicator of cardiac function.
  • Coronary artery disease (CAD) significantly impacts cardiac hemodynamics.

Purpose of the Study:

  • To investigate the correlation between LVEDP and the presence, extent, and severity of coronary artery disease (CAD).
  • To assess the clinical utility of LVEDP measurement in patients undergoing coronary angiography (CAG).

Main Methods:

  • A retrospective analysis of 912 patients who underwent both left cardiac catheterization and coronary angiography (CAG).
  • Coronary artery disease (CAD) was assessed by CAG, and its extent/severity by the number of affected vessels and Gensini score.
  • Statistical analysis, including correlation and linear regression, was used to evaluate LVEDP relationships.

Main Results:

  • Patients with CAD had significantly higher LVEDP compared to those without CAD (10.9±5.46 mmHg vs 9.58±5.78 mmHg, P<0.001).
  • LVEDP showed a significant independent correlation with the presence of CAD (OR = 0.11 per 5 mmHg increase, P = 0.02).
  • LVEDP increased with the number of diseased vessels and was significantly associated with the Gensini score (standardized β = 0.034, P = 0.001). In non-CAD patients, LVEDP correlated only with age.

Conclusions:

  • Elevated LVEDP is significantly associated with the presence, extent, and severity of coronary artery disease (CAD).
  • LVEDP measurement provides incremental clinical value for assessing cardiovascular risk in both CAD and non-CAD patients.
  • In patients without CAD, LVEDP was found to correlate solely with age.

Keywords:
Coronary artery diseaseGensini scoreleft ventricular end-diastolic pressure

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