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The prevalence of hyperprolactinemia in non-functioning pituitary macroadenomas
Fangfang Zhang1, Yinxing Huang2, Chenyu Ding3
1Department of Endocrinology, First Hospital of Fuzhou Affiliated to Fujian Medical University Fuzhou 350009, China.
International Journal of Clinical and Experimental Medicine
|January 16, 2016
Summary
Hyperprolactinemia occurs in 40.2% of non-functioning pituitary macroadenomas (NFPMAs). This high prevalence necessitates careful diagnosis to distinguish NFPMAs from prolactinomas.
Area of Science:
- Endocrinology
- Oncology
- Neurosurgery
Background:
- Non-functioning pituitary macroadenomas (NFPMAs) are tumors that do not secrete hormones.
- The co-occurrence of hyperprolactinemia in NFPMAs is not well-established, leading to diagnostic challenges.
Purpose of the Study:
- To determine the prevalence of hyperprolactinemia in patients with non-functioning pituitary macroadenomas.
- To address diagnostic uncertainty surrounding hyperprolactinemia in NFPMAs.
Main Methods:
- A comprehensive meta-analysis of studies indexed in PubMed was performed.
- Search terms focused on non-functioning pituitary tumors and hyperprolactinemia.
- Data extraction and analysis were conducted using STATA 11.0 with a fixed effects model.
Main Results:
- The meta-analysis included seven studies out of 57 initially identified.
- An overall prevalence of 40.2% (95% CI, 36.6%-43.7%) for hyperprolactinemia in NFPMAs was estimated.
Conclusions:
- The significant prevalence of hyperprolactinemia in NFPMAs underscores the need for careful diagnostic evaluation.
- Distinguishing between NFPMAs with hyperprolactinemia and prolactinomas requires meticulous assessment.
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