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Published on: November 14, 2020
Family history of Alzheimer's disease limits improvement in cognitive function after bariatric surgery
Michael L Alosco1, Mary Beth Spitznagel1, Gladys Strain2
1Department of Psychology, Kent State University, Kent, OH, USA.
Background/Objective:
Bariatric surgery can reverse cognitive impairments associated with obesity. However, such benefits may be attenuated in individuals with a predisposing risk for cognitive impairment such as family history of Alzheimer's disease.
Methods:
In all, 94 bariatric surgery participants completed a computerized cognitive test battery before and 12 weeks after surgery. Family history of Alzheimer's disease was obtained through self-report.
Results:
In the overall sample, cognitive function improved in memory and attention/executive function 12 weeks post-surgery. Repeated measures showed similar rates of improvements in attention/executive function between patients with and without a family history of Alzheimer's disease. In contrast, only individuals without a family history of Alzheimer's disease exhibited post-operative improvements in memory. A family history of Alzheimer's disease was associated with greater post-surgery rates of cognitive impairment.
Conclusions:
Family history of Alzheimer's disease may limit post-surgery cognitive benefits. Future studies should examine whether weight loss can modify the course of cognitive decline in patients at-risk for Alzheimer's disease.
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