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A Focused Screen Identifies Antifolates with Activity on Mycobacterium tuberculosis

Anuradha Kumar1, Ana Guardia2, Gonzalo Colmenarejo3

  • 1Center for Infectious Disease Research (Formerly Seattle Biomedical Research Institute) , Suite 500, Westlake Avenue North, Seattle, Washington 98109, United States.

ACS Infectious Diseases
|January 16, 2016
PubMed
Summary

Researchers identified novel antifolate compounds effective against Mycobacterium tuberculosis (Mtb). These promising drug candidates show potential for future tuberculosis treatment development, moving beyond current limitations.

Keywords:
antifolatedihydrofolate reductasetrimetrexatetuberculosis

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