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Updated: Mar 27, 2026

Comparing the Effects of Electronic Cigarette Vapor and Cigarette Smoke in a Novel In Vivo Exposure System
Published on: May 24, 2017
Cigarette Smoking and Electronic Cigarettes Use: A Meta-Analysis
Meng Wang1, Jian-Wei Wang2, Shuang-Shuang Cao3
1Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, Hangzhou 310051, China. mwang@cdc.zj.cn.
Cigarette smoking significantly increases the likelihood of using electronic cigarettes (e-cigarettes), with current smokers and adolescents showing the highest probabilities. This systematic review quantifies the strong association between combustible and electronic cigarette use.
Area of Science:
- Public Health
- Addiction Research
- Tobacco Control
Background:
- Cigarette smoking is a known risk factor for various health issues.
- Electronic cigarette (e-cigarette) use is rising, particularly among young people.
- The relationship between cigarette smoking and e-cigarette uptake requires systematic quantification.
Purpose of the Study:
- To systematically review and quantify the association between cigarette smoking and e-cigarette use.
- To compare the probability of e-cigarette use among current smokers versus ever smokers.
- To assess differences in this association between adolescents and adults.
Main Methods:
- A meta-analysis was conducted on relevant studies identified through searches of three databases up to June 2015.
- Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a random-effects model.
- The analysis focused on current and ever e-cigarette use in relation to smoking status and age group.
Main Results:
- Current smokers were significantly more likely to currently use e-cigarettes (OR: 14.89).
- The probability of current e-cigarette use was substantially higher in adolescents compared to adults (39.13% vs. 7.51%).
- Smokers had a significantly increased probability of ever using e-cigarettes (OR: 14.67), with higher probabilities observed in current smokers and adolescents.
Conclusions:
- Cigarette smoking is a strong predictor of e-cigarette use.
- The association is particularly pronounced among current smokers and adolescents.
- Findings highlight the need for targeted interventions to address dual use and prevent e-cigarette uptake among smokers.
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