Related Experiment Video
Updated: Mar 27, 2026
Oral Health Assessment by Lay Personnel for Older Adults
Published on: February 2, 2020
Validation of PHPQoL, a Disease-Specific Quality-of-Life Questionnaire for Patients With Primary Hyperparathyroidism
Susan M Webb1, M Puig-Domingo1, C Villabona1
1Endocrinology/Medicine Departments (S.M.W.), Hospital Sant Pau, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBER-ER), Unidad 747, Instituto de Salud Carlos III, IIB-Sant Pau, Universitat Autònoma de Barcelona, 08025 Barcelona, Spain; Endocrinology/Medicine Departments (M.P.-D.), Hospital Universitari Germans Trias i Pujol-Badalona, CIBER-ER, Grupo Clínico Vinculado U14, and CIBER of Diabetes and Associated Metabolic Diseases, Universitat Autònoma de Barcelona, 08916 Badalona, Spain; Hospital Universitari Bellvitge (C.V.), L'Hospitalet de Llobregat, 08907 Spain; Bone Metabolic Unit (RETICEF, Red Temática de Investigación Cooperative en Envejecimiento y Fragilidad) (M.M.-T.), Endocrinology Unit, Instituto de Investigación Biosanitaria de Granada, Hospital Universitario San Cecilio, 18012 Granada, Spain; Hospital Universitario de la Princesa and CIBER-ER Grupo Clínico Vinculado U12 (M.M.), 28006 Madrid, Spain; Hospital Virgen de la Victoria (D.F.), 29010 Málaga, Spain; Hospital 12 de Octubre (G.M.), 28041 Madrid, Spain; Hospital Universitario Quirón (E.J.), 28223 Madrid, Spain; Hospital Virgen del Rocío (M.A.M.), 41013 Sevilla, Spain; and IMS Health S.A. (N.P., X.B.), 08034 Barcelona, Spain.
Context:
Health-related quality of life (HRQoL) is impaired in primary hyperparathyroidism (PHPT) but instruments to specifically assess this are scarce.
Objective:
Validate the new disease-specific Primary Hyperparathyroidism Quality of Life (PHPQoL) questionnaire in usual clinical practice.
Design:
Observational, prospective, and multicenter.
Setting:
Public hospital ambulatory care.
Patients:
Patients with PHPT of both sexes, aged more than or equal to 18 years either initiated treatment for PHPT (group A) or had stable PHPT, not requiring therapy (group B). Patients in group A had at least one surgical criterion according to the 2009 Third International Workshop on Management of Asymptomatic PHPT.
Intervention:
Sociodemographic, clinical, and HRQoL data (PHPQol, Short Form-36, Psychological Well-Being Index, and patients' self-perceived health status) were collected. Group A underwent 4 evaluations (baseline, 3 ± 1, 6 ± 1, and 12 ± 2 months after a therapeutic intervention) and group B 2, at baseline and 1 month later to assess test-retest reliability.
Results:
A total of 182 patients were included (104 group A, 78 group B) with a mean age (SD) of 61.4 (12.1) years; 79.7% were women. Group A increased PHPQoL score (SD) (better HRQoL) (52 ± 23 at baseline; 62 ± 24 at 12 months; P < .001). At baseline, symptomatic patients had a lower PHPQoL score (worse) than asymptomatic ones (51 ± 21 vs 68 ± 21; P < .001). Correlations were seen between PHPQoL and Short Form-36, Psychological Well-Being Index, and self-perceived health status (P < .001). PHPQoL had good internal consistency (Cronbach's α = 0.80), test-retest reliability (group B, intraclass correlation coefficient > 0.80), and sensitivity to detect HQRoL changes over time.
Conclusions:
PHPQoL is a valid HRQoL measure to assess the impact of PHPT on health perception in clinical practice.
Related Concept Videos
00:59The Parathyroid Glands
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
01:21Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
01:29Assessment of the Gastrointestinal System II: Health Perception Pattern
Health Perception Patterns
Health perception patterns offer valuable insights into a patient's lifestyle habits and how they may impact their GI health. These patterns include:
01:27Peripheral Artery Disease III: Interprofessional Care
01:26Peripheral Artery Disease IV: Nursing Management
01:28Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.