Heparin-induced white clot syndrome

Heparin-induced thrombocytopenia and thrombosis (white clot syndrome) is a devastating clinical problem as illustrated by the case presented. A high index of suspicion is required to make the diagnosis. Management included discontinuing heparin and administering alternative forms of anticoagulation. Surgery on both the arterial and venous systems may be required. Fibrinolytic therapy as well as antiplatelet therapy may at times be necessary. The mortality rate is high and prevention is of key importance.