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Developing a Rat Model for Bipolar Disorder
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The development of lurasidone for bipolar depression
Antony Loebel1, Jane Xu1, Jay Hsu1
1Sunovion Pharmaceuticals Inc., Fort Lee, New Jersey, and Marlborough, Massachusetts.
Annals of the New York Academy of Sciences
|January 16, 2016
Summary
Lurasidone offers a new treatment for bipolar depression, proving effective alone or with other medications. This atypical antipsychotic provides a favorable risk-benefit profile for managing this disabling mood disorder.
Area of Science:
- Neuroscience
- Psychiatry
- Pharmacology
Background:
- Bipolar disorder is a leading cause of disability, with depressive episodes becoming more prevalent as the illness progresses.
- Limited effective treatments exist for bipolar depression, necessitating novel therapeutic approaches.
- Lurasidone, an atypical antipsychotic, was repurposed for bipolar depression, addressing a significant unmet medical need.
Purpose of the Study:
- To review the clinical development program for lurasidone in bipolar depression.
- To characterize the efficacy and safety of lurasidone for treating bipolar depression.
- To highlight lurasidone's unique development pathway from schizophrenia to bipolar depression treatment.
Main Methods:
- Review of key results from a clinical development program.
- Assessment of efficacy and safety data for lurasidone in bipolar depression patients.
- Analysis of lurasidone's performance as monotherapy and adjunctive therapy.
Main Results:
- Lurasidone demonstrated efficacy in treating bipolar depression.
- The drug is approved as both monotherapy and adjunctive therapy with lithium or valproate.
- Lurasidone presents a favorable risk-benefit profile for patients.
Conclusions:
- Lurasidone is a valuable new treatment option for bipolar depression.
- Its approval expands therapeutic choices for patients with this condition.
- Lurasidone offers an effective and safe treatment with a good risk-benefit profile.
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