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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Prediction of all-cause death in hemodialysis patients using elevated postdialysis pulse wave velocity
Xiaohong Fu1, Jihong Yang, Zhaoxin Fan
1Department of Geriatric Medicine, and Department of Nephrology, Beijing Hospital, Beijing, China.
Background:
To identify the relationship between predialysis pulse wave velocity (PWV), postdialysis PWV during 1 hemodialysis (HD) session, and deaths in maintenance HD patients.
Methods:
43 patients were recruited. PWV was measured before and after one HD session and dialysis- related data were recorded. Clinical data such as blood pressure, blood lipids, and blood glucose, were carefully observed and managed in a 5-year follow-up. The association between all-cause death, predialysis PWV, postdialysis PWV, change of PWV (ΔPWV), and other related variables were analyzed.
Results:
After 5 years, 17 patients (39.5%) died. Univariate Cox regression analysis showed that all-cause death of the patients significantly correlated with age, postdialysis PWV, and ΔPWV. Multivariate Cox regression analysis revealed that postdialysis PWV was an independent predictor for all-cause death in these patients (HR: 1.377, 95% CI: 1.146 - 1.656, p = 0.001).
Conclusion:
Elevated postdialysis PWV significantly correlated with and was an independent predictor for all-cause death in maintenance HD patients.
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