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Cytogenetically confirmed low-grade fibromyxoid sarcoma arising from the tibia
Peter M Mazari1, Kristy L Weber2, Sung Kim3
1Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104.
Human Pathology
|January 17, 2016
Summary
Low-grade fibromyxoid sarcoma, a rare tumor, was confirmed as a primary bone tumor in the tibia. This rare presentation highlights the importance of early diagnosis for this aggressive neoplasm.
Area of Science:
- Oncology
- Pathology
- Genetics
Background:
- Low-grade fibromyxoid sarcoma (LGFMS) is a rare soft tissue neoplasm.
- LGFMS exhibits benign histology but an aggressive clinical course, necessitating early diagnosis.
- The characteristic FUS-CREB3L2 fusion gene resulting from a 7;16 translocation is key for diagnosis.

