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Related Experiment Videos

Acceptable cancer risks: probabilities and beyond.

P F Ricci, L A Cox, J P Dwyer

    JAPCA
    |August 1, 1989
    PubMed
    Summary
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    Cancer risk assessment needs more than just numbers; it requires considering qualitative factors like responsibility and equity. A new portfolio approach offers provisional acceptability for managing cancer risks with uncertain scientific data.

    Area of Science:

    • Environmental Health
    • Risk Assessment
    • Public Health Policy

    Background:

    • Cancer risk assessment traditionally relies on quantitative measures like individual lifetime risk.
    • Qualitative evidence from animal and epidemiological studies is increasingly used but often insufficient.
    • Many crucial non-quantitative factors influencing risk acceptability are frequently overlooked.

    Purpose of the Study:

    • To demonstrate the limitations of simple, quantitative cancer risk measures.
    • To highlight the importance of incorporating non-quantitative factors into risk assessment.
    • To propose a novel framework for managing cancer risks.

    Main Methods:

    • Analysis of current risk assessment methodologies and their shortcomings.
    • Exploration of legal and regulatory standards influencing risk assessment.

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  • Development of a "portfolio approach" for cancer risk management.

    • Main Results:

    • Simple risk measures are often inadequate and fail to capture the full scope of risk acceptability.
    • Existing methods neglect essential elements such as responsibility, equity, and procedural legitimacy.
    • The proposed portfolio approach integrates diverse factors for a more comprehensive risk evaluation.

    Conclusions:

    • A shift from purely quantitative to a more holistic risk assessment is necessary.
    • The portfolio approach provides a structured method for managing cancer risks under scientific uncertainty.
    • This approach leads to "provisional acceptability," acknowledging decision-maker choices and trade-offs.