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Related Experiment Videos

Colic and the effect of changing formulas: a double-blind, multiple-crossover study.

B W Forsyth1

  • 1Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06510.

The Journal of Pediatrics
|October 1, 1989
PubMed
Summary

Switching infant formula, particularly from cow milk to Nutramigen, can reduce colic symptoms. However, this effect decreases over time and is not always reproducible.

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Area of Science:

  • Pediatrics
  • Gastroenterology
  • Nutrition

Background:

  • Infant colic is a common condition with significant distress for infants and families.
  • Previous studies on formula changes for colic have methodological limitations.
  • Identifying effective interventions for infant colic remains a priority.

Purpose of the Study:

  • To investigate the efficacy of formula changes in managing infant colic.
  • To address and improve upon the methodological flaws of prior research.
  • To assess the reproducibility and duration of formula effects on colic.

Main Methods:

  • A randomized, double-blind trial involving 17 colicky infants.
  • Alternating 4-day periods of casein hydrolysate (Nutramigen) and cow milk formula.

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  • Mothers recorded crying and colic episodes in diaries.
  • Washout periods and blinding were implemented to enhance study rigor.

    • Main Results:

    • Nutramigen significantly reduced crying and colic compared to cow milk formula during the first change (p<0.01).
    • A significant reduction in colic, but not crying, was observed with Nutramigen during the second change (p<0.05).
    • No significant differences were found between formulas by the third change; however, clinically meaningful responses favored Nutramigen (p<0.05).

    Conclusions:

    • Eliminating cow milk formula can improve colic in some infants.
    • The positive effect of formula change diminishes with repeated exposure.
    • The effect of formula changes on infant colic is often not consistently reproducible.