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A GC-FID method for quantitative analysis of N,N-carbonyldiimidazole
1Department of Process and Analytical Chemistry, Merck Research Laboratories, Merck & Co., Inc., Rahway, NJ 07065, United States.
Journal of Pharmaceutical and Biomedical Analysis
|January 17, 2016
Abstract:
N,N-Carbonyldiimidazole (CDI), a common synthetic reagent used in commercial scale pharmaceutical synthesis, is known to be sensitive to hydrolysis from ambient moisture. This liability demands a simple, robust analytical method to quantitatively determine reagent quality to ensure reproducible performance in chemical reactions. This work describes a protocol for a rapid GC-FID based analysis of CDI.
