Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bioreactor Controls-III01:22

Bioreactor Controls-III

51
Strain improvement is a foundational strategy in industrial microbiology aimed at maximizing microbial productivity, particularly because natural isolates typically yield commercially valuable products in very low concentrations. Although optimizing the culture medium and environmental conditions can improve yields, these adjustments are inherently limited by the organism’s genetic potential. As a result, the focus shifts toward genetic modifications to enhance biosynthetic capacity. The...
51
Production of Organic Acids01:25

Production of Organic Acids

61
Lactic acid, an important organic acid extensively applied in food, pharmaceutical, and biodegradable polymer industries, is primarily produced via microbial fermentation. This method is favored over chemical synthesis due to its environmental sustainability and capacity for enantiomerically pure product formation. Among various microbial processes, the fermentation of starch-based substrates stands out due to the abundance and renewability of raw materials like corn and potatoes.Hydrolysis of...
61
Scale-Up Processes01:14

Scale-Up Processes

35
The scale-up of microbial fermentation processes is essential in industrial biotechnology, allowing the transition from laboratory-scale experiments to commercial-scale production while aiming to maintain product yield and quality. This process requires meticulous adjustment of equipment design, process parameters, and contamination control strategies to accommodate increasing culture volumes.At the laboratory scale, cultures are typically maintained in 1 to 10-liter glass or autoclavable...
35
Production of Antibiotics01:27

Production of Antibiotics

31
Penicillin, one of the earliest and most widely used antibiotics, is produced industrially by the filamentous fungus Penicillium chrysogenum. Large stirred-tank bioreactors ranging from tens to hundreds of thousands of liters maintain tightly controlled temperature, pH, and dissolved oxygen conditions to support fungal metabolism and maximize antibiotic yield. Penicillin is a secondary metabolite, synthesized primarily during the stationary growth phase, which requires a carefully managed...
31
Upstream Processing01:27

Upstream Processing

36
Upstream processing represents a critical phase in biomanufacturing, wherein biological systems such as microorganisms, mammalian cells, or insect cells are cultivated to produce therapeutic proteins, vaccines, enzymes, or other biologically derived products. This phase encompasses all steps from the selection and genetic manipulation of the production organism to the cultivation of cells in bioreactors under tightly controlled environmental conditions.Host Selection and Genetic OptimizationThe...
36
Microbes in Food Production01:29

Microbes in Food Production

68
Microbial fermentation is central to food biotechnology, enhancing flavor, texture, preservation, and stability. Fermentative microorganisms metabolize carbohydrates into organic acids, alcohols, and other metabolites that inhibit spoilage organisms and improve digestibility while contributing distinctive sensory qualities.In baking, amylases naturally present in flour hydrolyze starch into monosaccharides such as glucose, which Saccharomyces cerevisiae ferments anaerobically. Through...
68

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessment of Complementary Catalysts in an Uncharted Enantioselective Reaction of Sulfondiimines.

Journal of the American Chemical Society·2026
Same author

Chiral methionine oxidation reagents reveal stereospecific proteome modifications.

bioRxiv : the preprint server for biology·2026
Same author

Stereoselective Generalizations over Diverse Sets of Chiral Acids Enabled by Buried Volume.

Journal of the American Chemical Society·2026
Same author

Random heteropolymers as enzyme mimics.

Nature·2025
Same author

Attractive Noncovalent Interactions versus Steric Confinement in Asymmetric Supramolecular Catalysis.

Journal of the American Chemical Society·2025
Same author

Profiling the proteome-wide selectivity of diverse electrophiles.

Nature chemistry·2025

Related Experiment Video

Updated: Mar 27, 2026

Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology
06:24

Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology

Published on: December 15, 2017

10.8K

Combining microbial production with chemical upgrading.

Konstantinos A Goulas1, F Dean Toste2

  • 1Department of Chemistry, University of California, Berkeley, CA 94720, USA; Department of Chemical and Biomolecular Engineering, University of California, Berkeley, CA 94720, USA; Energy Biosciences Institute, University of California, Berkeley, CA 94720, USA.

Current Opinion in Biotechnology
|January 17, 2016
PubMed
Summary
This summary is machine-generated.

This review covers chemical processing of fermentation products like ethanol and lactic acid into green fuels and chemicals. It highlights catalysts for sustainable biomass conversion into valuable compounds.

More Related Videos

Light-Controlled Fermentations for Microbial Chemical and Protein Production
08:37

Light-Controlled Fermentations for Microbial Chemical and Protein Production

Published on: March 22, 2022

4.8K
Methods for Facilitating Microbial Growth on Pulp Mill Waste Streams and Characterization of the Biodegradation Potential of Cultured Microbes
16:33

Methods for Facilitating Microbial Growth on Pulp Mill Waste Streams and Characterization of the Biodegradation Potential of Cultured Microbes

Published on: December 12, 2013

10.1K

Related Experiment Videos

Last Updated: Mar 27, 2026

Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology
06:24

Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology

Published on: December 15, 2017

10.8K
Light-Controlled Fermentations for Microbial Chemical and Protein Production
08:37

Light-Controlled Fermentations for Microbial Chemical and Protein Production

Published on: March 22, 2022

4.8K
Methods for Facilitating Microbial Growth on Pulp Mill Waste Streams and Characterization of the Biodegradation Potential of Cultured Microbes
16:33

Methods for Facilitating Microbial Growth on Pulp Mill Waste Streams and Characterization of the Biodegradation Potential of Cultured Microbes

Published on: December 12, 2013

10.1K

Area of Science:

  • Biotechnology and Chemical Engineering
  • Sustainable Chemistry

Background:

  • Fermentation yields key platform chemicals such as ethanol, lactic acid, 2,3-butanediol, and acetone-butanol-ethanol mixtures.
  • These bio-derived compounds offer potential as sustainable alternatives to petroleum-based products.

Purpose of the Study:

  • To review advancements in the chemical conversion of fermentation-derived compounds.
  • To explore pathways for producing drop-in fuels, polymers, and commodity chemicals.
  • To emphasize the role of catalysis in green chemical production from biomass.

Main Methods:

  • Literature review of chemical processing techniques.
  • Analysis of catalytic pathways (homogeneous and heterogeneous).
  • Focus on conversion of specific fermentation products: ethanol, lactic acid, 2,3-butanediol, ABE mixture.

Main Results:

  • Established pathways for converting bio-based platform chemicals into valuable products.
  • Demonstrated the utility of various catalysts in achieving efficient and green chemical transformations.
  • Highlighted the potential for biomass valorization into fuels and high-value chemicals.

Conclusions:

  • Chemical processing of fermentation products is crucial for sustainable chemical industries.
  • Catalysis plays a vital role in developing environmentally friendly routes from biomass.
  • Significant opportunities exist for producing drop-in fuels and chemicals from renewable resources.