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Updated: Mar 27, 2026

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
In-Stent Restenosis Caused by a Calcified Nodule: A Novel Pattern of Neoatherosclerosis
Fernando Alfonso1, Javier Cuesta1, Teresa Bastante1
1Hospital Universitario de La Princesa, Madrid, Spain.
Abstract:
Neoatherosclerosis has been described as a cause of in-stent restenosis (ISR), particularly in patients treated with drug-eluting stents (DESs). Although neoatherosclerosis may present as calcified plaques, the occurrence of a "calcified nodule" within the stent has not been previously reported. We describe optical coherence tomographic findings in a patient presenting with a calcified nodule causing "undilatable" ISR 2 years after implantation of a DES. The clinical and technical implications of this novel pattern of neoatherosclerosis are discussed.
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