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Updated: Mar 27, 2026

Immuno-fluorescence Assay of Leptospiral Surface-exposed Proteins
Published on: July 1, 2011
Characterization of IgA1 protease as a surface protective antigen of Streptococcus suis serotype 2
Lei Fu1, Jianqing Zhao2, Lan Lin3
1National Key Laboratory of Agricultural Microbiology, 1 Shizishan Street, Wuhan, Hubei, 430070, China; College of Veterinary Medicine, Huazhong Agricultural University, 1 Shizishan Street, Wuhan, Hubei, 430070, China.
Abstract:
IgA1 protease of Streptococcus suis serotype 2 (SS2) has been proven to be relative with virulence and immunogenicity, however, its protective efficacy remained to be evaluated. The present study found evidence that immunization with purified recombinant IgA1 protease (600-1926aa) could induce high IgG antibody titers and could confer complete protection against a challenge with a lethal dose of SS2 in a mouse model. In addition, our findings confirmed that the IgA1 protease distributes on the surface of SS2. Therefore, the present study identified the virulence-associated protein, IgA1 protease, as a novel surface protective antigen of SS2.
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