Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Antithrombotic drugs].

T Matsuda

    Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
    |March 1, 1989
    PubMed
    Summary
    This summary is machine-generated.

    Elderly individuals face increased thrombosis risk due to aging factors and atherosclerosis. Low-dose aspirin effectively inhibits thromboxane B2, a key factor in platelet aggregation, potentially reducing thrombotic events.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Tachyphylaxis to capsaicin-induced cough and its reversal by indomethacin, in patients with the sinobronchial syndrome.

    Clinical autonomic research : official journal of the Clinical Autonomic Research Society·1992
    Same author

    Locally invasive pulmonary aspergillosis in a healthy man successfully treated with oral fluconazole.

    Internal medicine (Tokyo, Japan)·1992
    Same author

    Abnormal distribution of IL-6 receptor in aged MRL/lpr mice: elevated expression on B cells and absence on CD4+ cells.

    International immunology·1992
    Same author

    Enterovesical fistula caused by inflammatory bowel diseases.

    Nihon Ika Daigaku zasshi·1992
    Same author

    Lactate in rat skeletal muscle after hemorrhage measured by microdialysis probe calibrated in situ.

    The American journal of physiology·1992
    Same author

    Peptidyl antithrombogenic agents for extracorporeal blood circulation.

    The International journal of artificial organs·1992
    Same journal

    [[Overview] Current status and challenges of ACP for older adults].

    Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·2026
    Same journal

    [Preface to the special issue on "Efforts for better advance care planning for older adults - Current situation and challenges in Japan"].

    Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·2026
    Same journal

    [Japan-multimodal intervention trial for prevention of dementia (J-MINT) and its societal implementation: Concepts, challenges, and future directions].

    Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·2026
    Same journal

    [Frontlines in geriatrics: Polypharmacy, the key revisions of the 2025 guidelines for medical treatment and its safety in the elderly].

    Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·2026
    Same journal

    [Erratum].

    Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·2026
    Same journal

    Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·2026
    See all related articles

    Area of Science:

    • Gerontology
    • Cardiovascular Medicine
    • Pharmacology

    Context:

    • Aging increases thrombotic tendency due to fibrinogen and antithrombin III changes.
    • Atherosclerosis is a primary cause of thrombosis in the elderly.
    • Anticoagulant therapy in the aged carries a higher risk of hemorrhage, particularly intracranial hemorrhage.

    Purpose:

    • To investigate the effect of low-dose aspirin on platelet aggregation and thromboxane B2 production in volunteers.
    • To evaluate the safety and efficacy of antithrombotic therapies in the elderly population.

    Summary:

    • Aspirin administration significantly reduced serum thromboxane B2 levels by inhibiting platelet cyclo-oxygenase.
    • Prostacyclin metabolite (6-keto-PGF1 alpha) levels remained largely unchanged, suggesting localized effects.

    Related Experiment Videos

  • The study highlights the risks of intracranial hemorrhage and peptic ulcers associated with aspirin therapy in the elderly.

    • Impact:

    • Findings suggest potential benefits of low-dose aspirin in managing thrombotic risk in the elderly.
    • Identifying individuals predisposed to thrombosis through biomarkers like fibrinogen may optimize antithrombotic therapy.
    • Further research is needed to balance the benefits of antithrombotic therapy against the risks of bleeding in aging populations.