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Related Concept Videos

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

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Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
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The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
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Recent progresses in bioadhesive microspheres via transmucosal administration.

Yan Jiao1, Xin Pang2, Mengrui Liu3

  • 1Department of Pharmaceutics, College of Pharmacy, Shandong University, Jinan 250012, China.

Colloids and Surfaces. B, Biointerfaces
|January 18, 2016
PubMed
Summary

This review explores bioadhesive microspheres (MSs) for transmucosal drug delivery, highlighting cell-adhesive and stimuli-responsive systems for targeted administration. Future research should focus on advanced materials and clinical applications.

Keywords:
Bioadhesive microspheresBioavailabilityStimuli-responsiveTransmucosal administration

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Area of Science:

  • * Pharmaceutical Sciences
  • * Biomaterials Science
  • * Drug Delivery Systems

Background:

  • * Adhesion preparations offer advantages for drug delivery.
  • * Microspheres (MSs) are increasingly utilized in mucosal drug delivery.
  • * Bioadhesive MSs are crucial for transmucosal administration via various routes.

Purpose of the Study:

  • * To review bioadhesive MSs for transmucosal administration.
  • * To discuss cell-adhesive and novel bioadhesive MSs.
  • * To explore advances in cell-selective and stimuli-responsive MSs for targeted drug delivery.

Main Methods:

  • * Comprehensive literature review of bioadhesive microspheres.
  • * Analysis of research on cell-adhesive and stimuli-responsive MSs.
  • * Examination of transmucosal administration routes and their efficacy.

Main Results:

  • * Bioadhesive MSs demonstrate potential for targeted drug delivery across mucosal membranes.
  • * Cell-adhesive MSs and stimuli-responsive MSs represent significant advancements.
  • * These systems offer enhanced drug localization and efficacy in specific tissues.

Conclusions:

  • * Bioadhesive MSs show promise for advanced drug delivery applications.
  • * Further research is needed on underlying mechanisms and novel bioadhesive materials ('second generation mucoadhesives').
  • * Clinical translation and application of these novel MSs require detailed investigation.