Gestational Trophoblastic Neoplasia Metastasis to the Pituitary: A Case Report

Pituitary metastasis secondary to gestational trophoblastic neoplasia (GTN) is an extremely rare condition that has not been previously reported in the literature.

A 23-year-old female presented with symptoms of amenorrhea for 6 months. She was diagnosed with choriocarcinoma, and chemotherapy was scheduled. Three months after drug withdrawal she complained of headache and visualfield defects. Brain magnetic resonance images showed suprasellar and intrasellar space-occupying lesions. Pituitary metastasis of choriocarcinoma was considered. She received etoposide, methotrexate, actinomycin, etoposide, and cisplatinum multiagent chemotherapy combined with intrathecal methotrexate administration. Complete radiological remission was obtained after cessation of chemotherapy. During the 13-month follow-up period no disease progression or recurrence was noted.

Pituitary metastasis of GTN is possible and is a curable disease that should be considered in young women with a history of choriocarcinoma who have neurologic symptoms. This metastasis responds well to chemotherapy.