Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Macrophage lipoprotein metabolism].

G Pifat-Mrzljak

    Lijecnicki Vjesnik
    |June 1, 1989
    PubMed
    Summary

    Macrophages utilize specific receptors to process cholesterol-rich lipoproteins, differing from other cells. This cholesterol scavenging may protect against foam cell formation in atherosclerosis.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same journal

    [Satisfaction of young doctors in Croatia: are we heading in the right direction?}.

    Lijecnicki vjesnik·2018
    Same journal

    [Empa-reg and leader trials -revolution in modern diabetology?].

    Lijecnicki vjesnik·2018
    Same journal

    [AUTONOMIC DYSREFLEXIA].

    Lijecnicki vjesnik·2018
    Same journal

    [ASSESSMENT OF QUALITY OF LIFE IN GLAUCOMA PATIENTS].

    Lijecnicki vjesnik·2018
    Same journal

    [HBsAg SEROCONVERSION IN THE TREATMENT OF CHRONIC HEPATITIS B WITH PEGYLATED INTERFERON].

    Lijecnicki vjesnik·2018
    Same journal

    [FEMUR FRACTURES IN CHILDREN – CAUSES AND MECHANISMS OF INJURY].

    Lijecnicki vjesnik·2018

    Area of Science:

    • Biochemistry
    • Cell Biology
    • Immunology

    Context:

    • Macrophages play a crucial role in lipid metabolism and immune responses.
    • Understanding macrophage lipoprotein uptake is vital for studying atherosclerosis.
    • Distinct mechanisms govern lipoprotein processing in macrophages versus other cell types.

    Purpose:

    • To review the specific mechanisms of lipoprotein uptake and cholesterol processing by macrophages.
    • To differentiate macrophage lipoprotein receptors from those in fibroblasts and smooth muscle cells.
    • To explore the role of macrophage cholesterol metabolism in preventing foam cell formation.

    Summary:

    • Macrophages possess unique "scavenger" receptors and beta-VLDL receptors for cholesterol-containing lipoproteins.
    • Non-regulated "scavenger" receptors bind modified low-density lipoproteins.
    • Familial dysbetalipoproteinemia involves poorly regulated beta-VLDL receptor mechanisms, leading to cholesterol ester accumulation.

    Impact:

    • Macrophage cholesterol ester processing involves a cholesterol-ester cycle.
    • Lack of extracellular cholesterol acceptors promotes cholesterol re-esterification and accumulation within macrophages.
    • Macrophage cholesterol scavenging is a key protective mechanism against foam cell formation and atherosclerosis development.

    Related Experiment Videos