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Dietary component isorhamnetin is a PPARγ antagonist and ameliorates metabolic disorders induced by diet or leptin

Yu Zhang1, Ming Gu1, Wujie Cai1

  • 1School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.

Scientific Reports
|January 19, 2016
PubMed

Insights

Isorhamnetin, a natural compound, acts as a novel peroxisome proliferator-activated receptor (PPAR)-γ antagonist. It effectively reduced obesity and ameliorated fatty liver disease, suggesting its therapeutic potential.

Area of Science:

  • Biochemistry
  • Metabolic Diseases
  • Natural Product Chemistry

Background:

  • Peroxisome proliferator-activated receptor (PPAR)-γ agonists are widely studied.
  • PPARγ activation is linked to obesity and nonalcoholic fatty liver disease (NAFLD).

Purpose of the Study:

  • To identify novel PPARγ antagonists.
  • To investigate the therapeutic potential of isorhamnetin against obesity and NAFLD.

Main Methods:

  • Identified isorhamnetin as a PPARγ antagonist.
  • Assessed isorhamnetin's effect on adipocyte differentiation.
  • Evaluated isorhamnetin's impact on diet-induced and leptin-deficient obesity and hepatic steatosis models.

Main Results:

  • Isorhamnetin inhibited rosiglitazone-induced adipocyte differentiation.
  • Isorhamnetin treatment reduced obesity development.
  • Isorhamnetin ameliorated hepatic steatosis in multiple models.

Conclusions:

  • Isorhamnetin is a novel PPARγ antagonist with anti-obesity and anti-steatosis properties.
  • Dietary isorhamnetin may prevent obesity and fatty liver disease.
  • PPARγ antagonists represent a potential therapeutic strategy for hepatic steatosis.

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