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Updated: Mar 27, 2026

Computed Tomography (CT) Guided Implantation of a Totally Implantable Venous Access Port (TIVAP) through Subclavian Vein
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Computed Tomography (CT) Guided Implantation of a Totally Implantable Venous Access Port (TIVAP) through Subclavian Vein

Published on: January 13, 2026

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Routine Antibiotic Prophylaxis for Totally Implantable Venous Access Device Placement: Meta-Analysis of 2,154

Evan Johnson1, James Babb1, Divya Sridhar1

  • 1Department of Radiology, Center for Biomedical Imaging, NYU Langone Medical Center, 660 First Avenue, New York, NY 10016.

Journal of Vascular and Interventional Radiology : JVIR
|January 19, 2016
PubMed
Abstract

Insights

Antibiotic prophylaxis for totally implanted venous access device (TIVAD) placement did not significantly reduce infection rates. This meta-analysis found no statistically significant difference in infections between patients who received antibiotics and those who did not.

Area of Science:

  • Medical Research
  • Infectious Disease Prevention
  • Vascular Access Devices

Background:

  • Totally implanted venous access devices (TIVADs) are crucial for long-term therapies.
  • Infection is a significant complication associated with TIVAD placement.
  • The role of antibiotic prophylaxis in preventing TIVAD-related infections remains debated.

Purpose of the Study:

  • To conduct a meta-analysis of existing literature on antibiotic prophylaxis during TIVAD placement.
  • To evaluate the efficacy of antibiotic prophylaxis in reducing infection rates following TIVAD insertion.

Main Methods:

  • Systematic review of MEDLINE/PubMed adhering to PRISMA guidelines.
  • Inclusion of four studies encompassing 2,154 patients undergoing TIVAD placement.
  • Comparison of infection rates between patients receiving antibiotic prophylaxis (n=360) and those not receiving it (n=1,794).

Main Results:

  • A total of 27 infections (1.25%) were identified post-TIVAD placement.
  • Infection rates were 1.39% in the antibiotic prophylaxis group and 1.23% in the nonprophylaxis group.
  • The odds ratio for infection was 0.84 (CI = 0.29-2.35), indicating no significant difference.

Conclusions:

  • Antibiotic prophylaxis use in TIVAD placement showed an odds ratio of 0.85 for infection.
  • The confidence interval included 1, suggesting no statistically significant reduction in infection rates.
  • Current evidence does not support routine antibiotic prophylaxis for TIVAD placement to prevent infections.

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