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Published on: February 17, 2018
Cardiomyopathy prevalence in 780 apparently healthy cats in rehoming centres (the CatScan study)
Jessie Rose Payne1, David Charles Brodbelt1, Virginia Luis Fuentes1
1Clinical Science and Services, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire, AL9 7TA, United Kingdom.
Insights
Hypertrophic cardiomyopathy (HCM) is common in apparently healthy cats, affecting 14.7% of those screened. Male sex, older age, higher body condition score, and heart murmurs are associated with HCM diagnosis in felines.
Area of Science:
- Veterinary Cardiology
- Feline Medicine
- Cardiovascular Research
Background:
- Hypertrophic cardiomyopathy (HCM) is a significant cardiac condition in cats.
- Pilot data suggested a potential prevalence of 15% in the feline population.
- Understanding HCM prevalence and risk factors is crucial for feline health.
Purpose of the Study:
- To screen a large cohort of apparently healthy adult cats for cardiac disease.
- To determine the prevalence of hypertrophic cardiomyopathy (HCM) in this population.
- To identify factors associated with a diagnosis of HCM in cats.
Main Methods:
- A prospective, cross-sectional study involving 780 apparently healthy cats aged ≥ 6 months.
- Exclusion of hypertensive or hyperthyroid cats.
- Evaluation included auscultation, blood pressure, and two-dimensional echocardiography; HCM defined by left ventricular wall thickness ≥ 6 mm.
Main Results:
- The prevalence of HCM was 14.7% (95% CI 12.3-17.4%), with higher prevalence in older cats.
- Heart murmur prevalence was 40.8%, with 70.4% deemed functional.
- Factors associated with HCM included male sex, increased age, higher body condition score, and louder heart murmurs.
Conclusions:
- Hypertrophic cardiomyopathy is a common cardiac condition in apparently healthy cats.
- Other cardiomyopathies are less prevalent in this population.
- Heart murmurs are frequent in cats but often functional, though associated with HCM risk.
Objectives:
Hypertrophic cardiomyopathy (HCM) appears to be common in cats and, based on pilot data, a prevalence of 15% has been hypothesized. The objectives were to screen a large population of apparently healthy adult cats for cardiac disease, and identify factors associated with a diagnosis of HCM.
Animals:
A total of 1007 apparently healthy cats ≥ 6 months of age.
Methods:
In this prospective, cross-sectional study, the inclusion criteria were: apparently healthy cats, aged ≥ 6 months, available for rehoming over a 17-month period from two rehoming centres. Hypertensive or hyperthyroid cats were excluded. Body weight, body condition score, auscultation, systolic blood pressure and two-dimensional (2-D) echocardiography were evaluated. Cats with left ventricular end-diastolic wall thickness ≥ 6 mm on 2-D echocardiography were considered to have HCM.
Results:
Complete data were obtained in 780 cats. Heart murmur prevalence was 40.8% (95% confidence interval (CI) 37.3-44.3%), 70.4% of which were considered functional. The prevalence of HCM was 14.7% (95% CI 12.3-17.4%), congenital disease 0.5% (95% CI 0.1-1.3%), and other cardiomyopathies 0.1% (95% CI 0.0-0.7%). The HCM prevalence increased with age. The positive predictive value of a heart murmur for indicating HCM was 17.9-42.6% (higher in old cats), and the negative predictive value was 90.2-100% (higher in young cats). The factors associated with a diagnosis of HCM in binary logistic regression models were male sex, increased age, increased body condition score and a heart murmur (particularly grade III/VI or louder).
Conclusions:
Hypertrophic cardiomyopathy is common in apparently healthy cats, in contrast with other cardiomyopathies. Heart murmurs are also common, and are often functional.
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