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A Conditioned Place Preference Protocol for Measuring Incubation of Craving in Rats

A Conditioned Place Preference Protocol for Measuring Incubation of Craving in Rats

Published on: November 6, 2018

Daily morphine administration increases impulsivity in rats responding under a 5-choice serial reaction time task.

D R Maguire¹, C Henson¹, C P France^1,2

¹Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.

British Journal of Pharmacology

|January 19, 2016

Summary

Repeated morphine administration increased motor impulsivity in rats, a key factor in drug abuse risk. Tolerance developed to other effects, but motor impulsivity worsened with daily opioid agonist use.

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Area of Science:

Neuroscience
Behavioral Pharmacology

Background:

Opioid agonists, like morphine, can increase impulsivity, particularly delay discounting.
The impact of repeated opioid agonist administration on motor impulsivity remains largely unexamined.

Purpose of the Study:

To investigate the effects of acute and repeated morphine administration on motor impulsivity in rats.
To assess whether tolerance develops to the motor impulsivity-enhancing effects of morphine.

Main Methods:

Rats were trained on a five-choice serial reaction time task, with premature responding serving as the index of motor impulsivity.
The effects of acute morphine and amphetamine were assessed before and during daily morphine administration over three weeks.

Main Results:

Acute morphine increased omissions and premature responding; amphetamine increased premature responding.
Following three weeks of daily morphine, tolerance developed to its effects on omissions.
Motor impulsivity, measured by premature responding, significantly increased with repeated morphine administration.

Conclusions:

Repeated morphine administration enhances motor impulsivity, despite tolerance to other effects.
Increased impulsivity due to opioid agonist use may elevate the risk for drug abuse.