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Updated: Mar 27, 2026

Functional Neuroimaging Using Ultrasonic Blood-brain Barrier Disruption and Manganese-enhanced MRI
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Published on: July 12, 2012

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Protection by Edaravone, a Radical Scavenger, against Manganese-Induced Neurotoxicity in Rats

Melda Apaydin1,2, Oytun Erbas3, Dilek Taskiran4

  • 1Department of Physiology, School of Medicine, Ege University, Izmir, Turkey.

Journal of Biochemical and Molecular Toxicology
|January 19, 2016
PubMed

Insights

Excessive manganese (Mn) exposure causes neurotoxicity and motor deficits in rats. Edaravone (EDA), a radical scavenger, effectively protected against these harmful effects, suggesting its therapeutic potential.

Area of Science:

  • Neuroscience
  • Toxicology
  • Biochemistry

Background:

  • Manganese (Mn) is essential but toxic at high levels, causing manganism.
  • Neurotoxicity from excessive manganese exposure is a significant health concern.

Purpose of the Study:

  • To assess subacute manganese exposure effects on rat neurotoxicity.
  • To evaluate edaravone's protective role against manganese-induced neurotoxicity.
  • To measure manganese accumulation in the brain using MRI.

Main Methods:

  • Rats were exposed to manganese, with some treated with edaravone.
  • Evaluated weight gain, motor performance, and brain mitochondrial biochemical parameters (Complex I activity, lipid peroxides, protein carbonyls).
  • Magnetic resonance imaging (MRI) was used to quantify manganese brain accumulation.

Main Results:

  • Manganese exposure impaired motor performance, caused weight loss, and increased brain manganese levels.
  • Mitochondrial oxidative stress markers (lipid peroxides, protein carbonyls) increased, while Complex I activity decreased.
  • Edaravone treatment mitigated oxidative damage and improved motor function.

Conclusions:

  • Subacute manganese exposure induces significant neurotoxicity and mitochondrial dysfunction in rats.
  • Edaravone demonstrates protective effects against manganese-induced neurotoxicity.
  • Edaravone shows potential as a therapeutic agent for manganese neurotoxicity.
Keywords:
EdaravoneMagnetic resonance imagingManganeseNeurotoxicityOxidative Stress

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