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Updated: Mar 27, 2026

Neuroimaging-Guided TMS–EEG for Real-Time Cortical Network Mapping
Published on: June 13, 2025
High frequency repetitive transcranial magnetic stimulation (rTMS) reduces EEG-hypofrontality in patients with
Daniel Kamp1, Jürgen Brinkmeyer1, Marcus W Agelink2
1Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine University, Bergische Landstr. 2, D-40629 Düsseldorf, Germany.
Abstract:
The reduced metabolic activity in the prefrontal brain lobes, so-called hypofrontality, is associated with increased electrophysiological delta-band activity. Schizophrenia inpatients (N=35) received sham-controlled 10Hz rTMS over the left dorsolateral prefrontal cortex in a randomised design. After treatment, the resting electroencephalography revealed a significant decrease in the delta-band activity, which originated in the right prefrontal cortex and correlated with improvements in facial affect recognition.

