Imposing Uniqueness to Achieve Sparsity
Related Experiment Video
Updated: Mar 27, 2026

Lensless Fluorescent Microscopy on a Chip
Published on: August 17, 2011
1Department of Biomedical Engineering, Tulane University, New Orleans, LA, USA.
Abstract:
In this paper we take a novel approach to the regularization of underdetermined linear systems. Typically, a prior distribution is imposed on the unknown to hopefully force a sparse solution, which often relies on uniqueness of the regularized solution (something which is typically beyond our control) to work as desired. But here we take a direct approach, by imposing the requirement that the system takes on a unique solution. Then we seek a minimal residual for which this uniqueness requirement holds. When applied to systems with non-negativity constraints or forms of regularization for which sufficient sparsity is a requirement for uniqueness, this approach necessarily gives a sparse result. The approach is based on defining a metric of distance to uniqueness for the system, and optimizing an adjustment that drives this distance to zero. We demonstrate the performance of the approach with numerical experiments.
Related Concept Videos
Second Uniqueness Theorem
In contrast, consider that the electric field is non-unique and apply Gauss's law in divergence form in the region between the conductors and the integral form to the surface...
Residuals and Least-Squares Property
If the observed data point lies above the line, the residual is positive, and the line underestimates the actual data value for y. If the observed data point lies below the line, the residual is negative, and the line overestimates the actual data value for y.
The process of fitting the best-fit...
Law of Independent Assortment
Law of Independent Assortment
Quantifying and Rejecting Outliers: The Grubbs Test
Compacting Factor test
The procedure begins by placing concrete into the upper hopper without any compaction. Once filled, the bottom door of this hopper is opened,...

