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Mast Cell: A Multi-Functional Master Cell.
Melissa Krystel-Whittemore1, Kottarappat N Dileepan2, John G Wood3
1Department of Molecular and Integrative Physiology, University of Kansas Medical Center , Kansas City, KS , USA.
Frontiers in Immunology
|January 19, 2016
Summary
Mast cells, immune cells found throughout the body, play key roles in both normal physiology and disease. This review details their involvement in various physiological functions and pathological conditions.
Area of Science:
- Immunology
- Cell Biology
Background:
- Mast cells are immune cells originating from the myeloid lineage.
- They reside in connective tissues globally, influencing numerous physiological and pathological processes.
Purpose of the Study:
- To review the multifaceted roles of mast cells.
- To summarize their involvement in both normal physiological functions and various disease states.
Main Methods:
- Literature review of current research on mast cells.
- Synthesis of information regarding mast cell functions and implications in disease.
Main Results:
- Mast cells regulate vasodilation, vascular homeostasis, immune responses, angiogenesis, and venom detoxification.
- They are implicated in the pathophysiology of allergies, asthma, anaphylaxis, gastrointestinal disorders, malignancies, and cardiovascular diseases.
Conclusions:
- Mast cells are critical players in a wide spectrum of biological processes.
- Understanding mast cell roles is essential for addressing numerous diseases.
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