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Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Mast cells are immune cells originating from the myeloid lineage.
  • They reside in connective tissues globally, influencing numerous physiological and pathological processes.

Purpose of the Study:

  • To review the multifaceted roles of mast cells.
  • To summarize their involvement in both normal physiological functions and various disease states.

Main Methods:

  • Literature review of current research on mast cells.
  • Synthesis of information regarding mast cell functions and implications in disease.

Main Results:

  • Mast cells regulate vasodilation, vascular homeostasis, immune responses, angiogenesis, and venom detoxification.
  • They are implicated in the pathophysiology of allergies, asthma, anaphylaxis, gastrointestinal disorders, malignancies, and cardiovascular diseases.

Conclusions:

  • Mast cells are critical players in a wide spectrum of biological processes.
  • Understanding mast cell roles is essential for addressing numerous diseases.