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Updated: Mar 27, 2026

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound
Published on: December 2, 2014
Association between aortic stiffness and left ventricular function in inflammatory bowel disease.
Abdullah Nabi Aslan1, Cenk Sarı, Sevil Özer Sarı
1Department of Cardiology, Ataturk Education and Research Hospital, Ankara, Turkey. drnabiaslan@hotmail.com.
Inflammatory bowel disease (IBD) patients show increased aortic stiffness and left ventricular (LV) dysfunction. This study confirms a significant relationship between aortic stiffness and LV systolic/diastolic dysfunction in IBD, aiding early cardiovascular risk prediction.
Area of Science:
- Cardiology
- Gastroenterology
- Vascular Biology
Background:
- Inflammatory bowel disease (IBD) is linked to higher rates of aortic stiffness and left ventricular (LV) dysfunction.
- The precise relationship between aortic stiffness and LV function in IBD patients remains unclear.
Purpose of the Study:
- To investigate the association between aortic stiffness and LV systolic and diastolic function in patients with IBD.
Main Methods:
- Echocardiography, including tissue Doppler, assessed LV systolic and diastolic functions.
- Aortic strain and distensibility were calculated using M-mode echocardiography and blood pressure.
- Seventy-two IBD patients and 50 healthy controls were included.
Main Results:
- IBD patients exhibited significant differences in aortic strain and distensibility compared to controls.
- LV systolic and diastolic function parameters also differed significantly between IBD patients and controls.
- Aortic stiffness was directly associated with LV function in the IBD cohort.
Conclusions:
- A significant relationship exists between aortic stiffness and LV systolic/diastolic dysfunction in IBD patients.
- Echocardiographic assessment of aortic elasticity parameters may help predict early cardiovascular risk in IBD.
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