Non-high-density lipoprotein cholesterol: current status as cardiovascular marker
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Updated: Mar 27, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
Rutger Verbeek1, G Kees Hovingh, S Matthijs Boekholdt
1aDepartment of Vascular MedicinebDepartment of Cardiology, Academic Medical Center, Amsterdam, the Netherlands.
Purpose Of Review:
In this review, we summarize the evidence with regard to the rationale of using nonhigh density lipoprotein cholesterol (non-HDL-C) as a cardiovascular disease (CVD) risk factor, in relation to low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (apoB).
Recent Findings:
In the 2015 National Lipid Association Annual Summary non-HDL-C is considered a coprimary target, apart from LDL-C. The other data published in the last 18 months about non-HDL-C support all the previous published data. There are no recent findings, which we deem to cause a change of the current opinion about non-HDL-C as a predictor for CVD.
Summary:
The existing evidence supports the claim that non-HDL-C is superior to LDL-C in CVD risk estimation.
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