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A Protocol for Analyzing Hepatitis C Virus Replication
Published on: June 26, 2014
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Hepatitis C reinfection after sustained virological response
Håvard Midgard1, Benedikte Bjøro2, Arild Mæland3
1Department of Infectious Diseases, Akershus University Hospital, Lørenskog, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Journal of Hepatology
|January 19, 2016
Summary
Hepatitis C virus (HCV) reinfection is common in people who inject drugs (PWID) after treatment, especially those who relapse to injecting drug use. Prevention strategies are crucial for HCV care in PWID.
Area of Science:
- Hepatology
- Infectious Diseases
- Public Health
Background:
- Ongoing risk behaviors can lead to hepatitis C virus (HCV) reinfection post-treatment.
- Sustained virological response (SVR) is achievable but reinfection remains a concern.
Purpose of the Study:
- To assess the incidence of persistent HCV reinfection.
- To evaluate HCV reinfection in people who inject drugs (PWID) achieving SVR.
Main Methods:
- A multicentre treatment trial (NORTH-C) in Scandinavia (2004-2006).
- Follow-up study of Norwegian patients (n=161) who achieved SVR.
- Assessment of virological and behavioral characteristics, including abstinence from injecting drug use (IDU).
Main Results:
- Persistent HCV reinfection occurred in 11% of those with prior IDU history and 27% of those relapsing to IDU post-treatment.
- Relapse to IDU strongly predicted reinfection (incidence rate 4.9/100 PY).
- Younger age (<30) and lower education were associated with relapse to IDU.
Conclusions:
- Persistent HCV reinfection is a significant issue for PWID who relapse to IDU after treatment.
- Systematic prevention and management of reinfection are essential in HCV care for PWID.
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