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Updated: Mar 27, 2026

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

Published on: July 24, 2020

Nonhuman Primate Ocular Biometry.

Robert C Augusteyn¹, Bianca Maceo Heilman², Arthur Ho¹

¹Vision Cooperative Research Centre, Sydney, Australia 2School of Optometry and Vision Science, University of New South Wales, Sydney, Australia 3Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miam.

Investigative Ophthalmology & Visual Science

|January 19, 2016

Summary

This summary is machine-generated.

Nonhuman primate ocular globe growth continues throughout life, while corneal growth stops early. Lens size changes with age, but caution is advised when extrapolating these findings to human accommodation studies.

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In Vivo Methods to Assess Retinal Ganglion Cell and Optic Nerve Function and Structure in Large Animals

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Published on: February 26, 2022

Area of Science:

Ophthalmology
Primate Biology
Comparative Anatomy

Background:

Understanding ocular development in nonhuman primates (NHPs) is crucial for comparative studies with humans.
Previous research has not fully detailed the lifelong ocular growth patterns in various NHP species.

Purpose of the Study:

To investigate and quantify ocular growth in nonhuman primates using ex vivo eye measurements.
To compare ocular growth parameters between different NHP species and with human ocular development.

Main Methods:

Excised globes from hamadryas baboons, cynomolgus monkeys, and rhesus monkeys (ages 23-360 months) were measured using digital calipers.
Globe and corneal diameters were recorded, alongside lens sagittal thickness and equatorial diameter via shadowphotogrammetry.
Lens wet and fixed dry weights were determined.

Main Results:

Nonhuman primate globe growth persists throughout life, approaching a maximum size that scales with body size.
Corneal growth ceased around 20 months of age.
Lens diameter increased with age, while thickness decreased; lens weight accumulation continued throughout life.

Conclusions:

Nonhuman primate ocular globe and lens growth patterns exhibit significant differences compared to humans.
While age-related changes in lens power and accommodation amplitude are similar, distinct lens growth properties necessitate caution when extrapolating NHP data to human accommodation research.