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Updated: Mar 27, 2026

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
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Current antiangiogenic agents in oncology and ophthalmology

M Cernak, L Nogova

    Neoplasma
    |January 20, 2016
    PubMed
    Abstract

    Insights

    Antiangiogenic drugs can cause ocular side effects in cancer patients but may also treat eye conditions. Oncologists and ophthalmologists should collaborate when using these agents.

    Area of Science:

    • Oncology
    • Ophthalmology
    • Pharmacology

    Background:

    • Antiangiogenic drugs have been used for over a decade for various cancers.
    • These agents are also approved for local ocular treatments like macular degeneration and diabetic retinopathy.

    Purpose of the Study:

    • To review literature on ocular side effects of systemic antiangiogenic drugs in cancer patients.
    • To investigate if these drugs can simultaneously treat ocular disorders in cancer patients.
    • To highlight the importance of oncologist-ophthalmologist collaboration.

    Main Methods:

    • Literature review of published papers.
    • Systematic search for studies on antiangiogenic agents, ocular side effects, and ocular conditions.

    Main Results:

    • Systemic antiangiogenic drugs can cause ocular side effects in cancer patients.
    • Evidence suggests potential therapeutic effects on ocular conditions in some patients.
    • Collaboration is crucial for managing these dual effects.

    Conclusions:

    • Antiangiogenic therapy requires careful monitoring for ocular side effects.
    • Potential benefits for co-existing ocular conditions should be considered.
    • Interdisciplinary communication between oncologists and ophthalmologists is essential.

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