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Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

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Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
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Pathophysiology of Diabetes01:20

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Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
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Diabetes: Symptoms, Diagnosis, and Complications01:15

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For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
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Diabetes Mellitus: Overview and Type I Subtype01:22

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Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
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Oral Hypoglycemic Agents: Biguanides and Glitazones01:26

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Biguanides, particularly metformin (Glucophage), are insulin sensitizers that enhance glucose uptake, thereby reducing insulin resistance. Unlike sulfonylureas, metformin doesn't prompt insulin secretion, which helps to curb hypoglycemia risk. Metformin is beneficial in treating conditions like polycystic ovary syndrome due to its insulin-resistance reduction capability. The drug's primary action involves curtailing hepatic gluconeogenesis, a significant contributor to high blood...
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Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
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A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
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[Screening for gestational diabetes: Still many unsolved issues].

S Bartolo1, A Vambergue2, P Deruelle3

  • 1Clinique d'obstétrique, pôle femme-mère-nouveau-né, CHU de Lille, 59037 Lille cedex, France.

Journal De Gynecologie, Obstetrique Et Biologie De La Reproduction
|January 20, 2016
PubMed
Summary
This summary is machine-generated.

Gestational diabetes screening in France is debated, with current methods potentially not meeting WHO criteria. The review questions the benefit of new screening criteria and highlights uncertainties in diagnosis and treatment effectiveness.

Keywords:
Diabète gestationnelDiagnosisDiagnosticDépistageGestational diabetesScreening

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Area of Science:

  • Obstetrics and Gynecology
  • Public Health
  • Endocrinology

Background:

  • Gestational diabetes (GD) is a significant public health concern with a partially understood natural history.
  • Debate exists regarding optimal screening tests and diagnostic thresholds for GD.
  • Current GD screening practices in France are under scrutiny regarding adherence to international guidelines.

Purpose of the Study:

  • To evaluate if current gestational diabetes screening in France aligns with the World Health Organization's (WHO) 10 definition criteria.
  • To assess the clinical utility and effectiveness of new GD screening criteria.

Main Methods:

  • Literature review assessing existing data on GD screening in France.
  • Analysis of screening tests, diagnostic criteria, and treatment protocols against WHO guidelines.
  • Review of studies on the impact of GD screening on maternal and fetal outcomes.

Main Results:

  • Current GD screening in France may not fully meet WHO criteria.
  • Evidence for the benefit of treating patients identified by new GD screening criteria is lacking.
  • The one-step screening approach primarily detects fetal, not maternal, complications.
  • Screening for GD may increase obstetric interventions, and its cost-effectiveness in the French context is uncertain.

Conclusions:

  • The current approach to gestational diabetes screening in France requires evaluation against WHO criteria.
  • Further research is needed to establish the benefits of new screening criteria and the reproducibility of diagnostic tests.
  • The impact of GD screening on obstetric interventions and its cost-effectiveness in France warrant further investigation.