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Updated: Mar 27, 2026

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
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Cangrelor-Mediated Cardioprotection Requires Platelets and Sphingosine Phosphorylation

Michael V Cohen1,2, Xi-Ming Yang3, James White3

  • 1Department of Physiology and Cell Biology, College of Medicine, University of South Alabama, Mobile, AL, USA. mcohen@southalabama.edu.

Cardiovascular Drugs and Therapy
|January 20, 2016
PubMed
Summary

Platelet P2Y12 receptor antagonists protect the heart via signaling, not just by preventing clots. This protection requires a blood factor, likely within platelets, and involves sphingosine kinase, similar to ischemic preconditioning.

Keywords:
CardioprotectionConditioningPlateletSphingosineSphingosine-1-phosphate

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