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Updated: Mar 27, 2026
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Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes
Published on: June 28, 2024
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[Correlation between neonatal vitamin D level and maternal vitamin D level]
Chen Wang1, Jin-Song Gao, Song-Lin Yu
1Department of Pediatrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China. danhuawang10@126.com.
Summary
Maternal vitamin D levels strongly correlate with neonatal vitamin D levels. Maternal vitamin D status can effectively predict vitamin D deficiency in newborns.
Area of Science:
- Obstetrics and Gynecology
- Neonatology
- Nutritional Science
Background:
- Vitamin D deficiency is a global health concern affecting both mothers and neonates.
- Adequate vitamin D is crucial for maternal health and fetal development.
- Understanding the relationship between maternal and neonatal vitamin D levels is vital for preventative strategies.
Purpose of the Study:
- To examine the correlation between maternal and neonatal vitamin D levels.
- To assess the predictive value of maternal vitamin D status for neonatal vitamin D deficiency.
Main Methods:
- Umbilical venous blood samples from 102 neonates and maternal venous blood samples were collected.
- Serum 25-hydroxyvitamin D [25(OH)D] levels were measured using ultra-performance liquid chromatography with isotope dilution.
Main Results:
- Vitamin D insufficiency and deficiency were prevalent in both mothers and neonates.
- A significant positive correlation (r=0.914, P<0.001) was observed between maternal and neonatal serum 25(OH)D levels.
- Maternal 25(OH)D levels demonstrated high accuracy in predicting neonatal vitamin D deficiency (AUC=0.962), with a sensitivity of 97.2% and specificity of 80.3% for levels ≤27.55 ng/mL.
Conclusions:
- Neonatal vitamin D levels are strongly associated with maternal vitamin D levels.
- Maternal vitamin D status serves as a reliable predictor of neonatal vitamin D deficiency.
- Monitoring maternal vitamin D may aid in early identification and management of neonatal vitamin D deficiency.
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