Upregulated Pdx1 and MafA Contribute to β-Cell Function Improvement by Sleeve Gastrectomy
Feng Li1, Han Cao1, Chunjun Sheng1
1Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tong-Ji University, 301 Middle Yan-Chang Road, Shanghai, 200072, China.
Purpose:
Sleeve gastrectomy is an effective technique for the treatment of severe obesity, and its effects on the improved β-cell function have not yet been fully understood.
Materials And Methods:
From February 2014 to July 2015, sleeve gastrectomy was performed in 5 patients with T2D, who were assessed before and after sleeve gastrectomy (SG). Moreover, a high-fat-diet (HFD) mouse model was also used to study the molecular mechanisms of β-cell functional improvement after SG.
Results:
The glucose-stimulated acute insulin response was restored in the T2D patients after SG. The expression of GLP-1 in colonic tissue as well as β-cell specific transcription factors (TFs), Pdx1, and MafA in islets was significantly increased after SG.
Conclusion:
β-cell dysfunction can be ameliorated by SG. The re-activation of key TFs contributes to the improvement of β cell function.
