Double blind study of a valerian preparation

Area of Science:

• Pharmacology and Herbal Medicine

Background:

• Valerian root contains valepotriates (cytotoxic) and sesquiterpenes (non-cytotoxic).
• Both compounds exhibit sedative effects.
• Valepotriates are used for drug standardization.

Purpose of the Study:

• To evaluate the efficacy of a valerian preparation (VALERINA NATT) rich in sesquiterpenes for improving sleep quality.
• To compare the effects of the sesquiterpene-rich preparation against a placebo.

Main Methods:

• A double-blind, placebo-controlled study was conducted.
• Participants received either the sesquiterpene-rich valerian preparation or a placebo.
• Sleep quality was assessed based on participant-reported outcomes.

Main Results:

• The valerian preparation demonstrated a significant positive effect on poor sleep (p < 0.001).
• 44% of participants reported perfect sleep, and 89% reported improved sleep.
• No adverse side effects were observed during the study.

Conclusions:

• A valerian preparation primarily containing sesquiterpenes is effective in improving sleep quality.
• This preparation offers a safe alternative for individuals experiencing sleep disturbances.