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Related Experiment Video

Updated: Mar 27, 2026

Peptide-based Identification of Functional Motifs and their Binding Partners

Peptide-based Identification of Functional Motifs and their Binding Partners

Published on: June 30, 2013

HIV-associated immune complex kidney disease.

Ehsan Nobakht¹, Scott D Cohen¹, Avi Z Rosenberg²

¹Division of Renal Diseases and Hypertension, Department of Medicine, George Washington University, 2150 Pennsylvania Avenue, NW #3-438, Washington, District of Columbia 20037, USA.

Nature Reviews. Nephrology

|January 20, 2016

Summary

Combination antiretroviral therapy (cART) has transformed HIV into a chronic condition, altering kidney disease patterns. This review explores HIV-associated immune complex kidney diseases (HIVICD), their diagnosis, and treatment.

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Establishment of the Dual Humanized TK-NOG Mouse Model for HIV-associated Liver Pathogenesis

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Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

Published on: December 3, 2019

Area of Science:

Nephrology
Immunology
Infectious Diseases

Background:

Combination antiretroviral therapy (cART) has shifted HIV infection from acute to a chronic manageable condition.
The epidemiology of kidney disease in HIV-infected patients has evolved, potentially due to cART.
HIV infection causes unique immunologic issues, leading to immune complex deposition and kidney injury.

Purpose of the Study:

To review HIV-associated immune complex kidney diseases (HIVICD).
To examine differential diagnoses, clinical manifestations, and underlying mechanisms of HIVICD.
To discuss treatment, outcomes, and research needs for HIVICD.

Main Methods:

Literature review of HIV-associated immune complex kidney diseases.
Analysis of clinical manifestations and immunologic mechanisms.
Examination of treatment strategies and patient outcomes.

Main Results:

HIVICD presents unique diagnostic challenges.
Understanding immunologic dysregulation is key to HIVICD pathogenesis.
cART's impact on HIVICD epidemiology is significant.

Conclusions:

Optimal diagnosis and treatment of HIVICD require further research.
Addressing research needs will improve patient care for HIVICD.
Comprehensive management strategies are crucial for patients with HIVICD.