Related Experiment Video
Updated: Mar 27, 2026
07:26
Systematic Assessment of Mammalian Skull Specimens for Dental and Temporomandibular Joint Pathology
Published on: August 22, 2022
2.0K
Systematic review of oral ulceration with bone sequestration
Benjamin Palla1, Egon Burian2, John Richard Klecker1
1Harvard School of Dental Medicine, Boston, MA, USA.
Summary
Oral ulceration with bone sequestration (OUBS) is a rare condition. This systematic review highlights the limited literature and calls for more research to understand its prevalence and impact on patients with ulcerative diseases and osteonecrosis.
Area of Science:
- Oral pathology
- Systematic reviews
- Bone diseases
Background:
- Oral ulceration with bone sequestration (OUBS) is a poorly defined oral disorder.
- This systematic review aims to define OUBS and assess its prevalence relative to other oral conditions involving ulceration and bone exposure.
Purpose of the Study:
- To systematically review and define oral ulceration with bone sequestration (OUBS).
- To determine the prevalence and characteristics of OUBS.
- To understand the significance of OUBS in the context of other oral disorders.
Main Methods:
- Systematic review registered with PROSPERO (CRD42015024294).
- Searches conducted in EMBASE, Medline, and PubMed using MeSH terms and proximity operators.
- Inclusion criteria focused on bone exposure without a known cause; PRISMA guidelines were followed.
Main Results:
- Only 8 articles and 24 patients met the criteria for OUBS.
- The mean age of affected patients was 43.21 years, with a 3:1 male to female ratio.
- The mandible was the most common site of occurrence (95.8%).
Conclusions:
- Literature on OUBS is scarce, necessitating further data generation.
- Increased knowledge of OUBS is crucial for accurate diagnosis and patient benefit.
- OUBS warrants further investigation due to its association with ulcerative diseases and osteonecrosis.
