Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Depression: Overview

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...

Pharmacodynamics in Geriatric Patients: Effects of Age

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

Long-term Depression

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.

Long-term Depression

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...

Depressive Disorders: MDD and Dysthymia

Depressive Disorders: MDD and Dysthymia

Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...

Drug Dosing: Geriatric Patients

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Psilocybin-Assisted Supportive Psychotherapy in the Treatment of Major Depression-Quo Vadis?

JAMA psychiatry·2020

Same author

Reply to: Say What?! Ableist Logic Used in Misguided Attempt to Combat Ageism During COVID-19.

Journal of the American Geriatrics Society·2020

Same author

Cortical inhibition, facilitation and plasticity in late-life depression: effects of venlafaxine pharmacotherapy.

Journal of psychiatry & neuroscience : JPN·2020

Same author

Insomnia subtypes and clinical impairment in hospitalized children with autism spectrum disorder.

Autism : the international journal of research and practice·2020

Same author

The Effect of Venlafaxine on Electrocardiogram Intervals During Treatment for Depression in Older Adults.

Journal of clinical psychopharmacology·2020

Same author

Telomere length and its relationships with lifestyle and behavioural factors: variations by sex and race/ethnicity.

Age and ageing·2020

Search research articles

Related Experiment Videos

Does a Depression Management Program Decrease Mortality in Older Adults with Specific Medical Conditions in Primary

Hillary R Bogner¹, Jin H Joo², Seungyoung Hwang³

¹Department of Family Medicine and Community Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Journal of the American Geriatrics Society

|January 20, 2016

Summary

This summary is machine-generated.

Treating depression in older adults with diabetes mellitus significantly reduced mortality risk. This intervention showed promise for managing depression and chronic conditions in primary care settings.

Keywords:

depression medical comorbidity primary care randomized clinical trial

Related Experiment Videos

Area of Science:

Geriatrics
Public Health
Clinical Medicine

Background:

Older adults with depression and chronic medical conditions present a significant health challenge.
Effective interventions are needed to reduce mortality in this vulnerable population.

Purpose of the Study:

To investigate if treating depression in older adults can decrease mortality from various chronic medical conditions.
To assess the impact of a depression care management intervention on mortality in elderly primary care patients.

Main Methods:

A multisite randomized controlled trial (Prevention of Suicide in Primary Care Elderly: Collaborative Trial) involving 1,226 individuals aged 60 and older.
Practices were randomized to either an intervention group receiving algorithm-based depression care or usual care for two years.
Mortality risk was assessed over a median follow-up of 98 months, with chronic conditions self-reported.

Main Results:

Individuals with major depression and diabetes mellitus in the intervention group showed a statistically significant reduction in mortality (hazard ratio=0.47).
For heart disease, major depression was associated with increased mortality risk regardless of treatment group.
Other medical conditions did not show statistically significant intervention effects on mortality, though trends favored the intervention.

Conclusions:

Treating depression in older adults with comorbid diabetes mellitus can significantly reduce mortality.
Depression management in primary care holds potential for improving outcomes in elderly patients with chronic conditions.
Addressing depression in medically complex older adults remains a critical public health priority.