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Treatment of Stable Angina Pectoris With Ivabradine in Everyday Practice: A Pan-Hellenic, Prospective,

John Zarifis1, Violetta Grammatikou2, Manolis Kallistratos2

  • 1Cardiology Department, "George Papanikolaou" General Hospital, Thessaloniki, Greece.

Clinical Cardiology
|January 20, 2016
PubMed

Insights

Adding ivabradine to beta-blockers significantly reduced angina symptoms and improved quality of life in coronary artery disease patients. This combination therapy demonstrated high patient compliance and effectiveness in managing chronic stable angina.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Coronary artery disease (CAD) management focuses on controlling ischemia and angina symptoms to improve quality of life (QOL).
  • Medical treatment is the primary strategy for patients with CAD.

Purpose of the Study:

  • To evaluate the antianginal efficacy of a 4-month treatment with ivabradine plus a beta-blocker in CAD patients.
  • To assess patient compliance and the impact of this combination therapy on QOL.

Main Methods:

  • A noninterventional study involving 2403 patients with chronic stable angina.
  • Data collected at baseline, 1 month, and 4 months, including EuroQol 5 dimensions (EQ-5D) for QOL assessment.

Main Results:

  • Significant reduction in heart rate, anginal attacks, and nitroglycerin use.
  • Increased percentage of patients in Canadian Cardiovascular Society angina class I.
  • Improved QOL scores (EQ-5D visual analogue scale) and high treatment compliance (96%).

Conclusions:

  • Ivabradine, when added to beta-blockers, effectively reduces anginal events in CAD patients.
  • This combination therapy significantly improves the quality of life for individuals with coronary artery disease.
Abstract

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