Related Experiment Video
Updated: Mar 27, 2026
09:59
A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia
Published on: September 16, 2017
14.7K
Can MRI quantification help evaluate stroke age?
Samuel Emeriau1, Azzedine Benaïssa1, Olivier Toubas1
1CHU de Reims, Reims University, Hôpital Maison-Blanche, Department of Neuroradiology, 45, rue Cognacq-Jay, 51092 Reims cedex, France.
Journal of Neuroradiology = Journal De Neuroradiologie
|January 20, 2016
Summary
Quantifying MRI signals can help estimate stroke timing, but visual assessment of diffusion-weighted imaging (DWI) and fluid-attenuated inversion recovery (FLAIR) mismatch remains more accurate for determining stroke-to-MRI delay.
Area of Science:
- Neurology
- Radiology
- Medical Imaging
Background:
- Diffusion-weighted imaging (DWI) and fluid-attenuated inversion recovery (FLAIR) mismatch is established for estimating stroke-to-magnetic resonance imaging (MRI) delay.
- This study investigated enhancing stroke dating accuracy by quantifying MRI signals (DWI and FLAIR) compared to visual mismatch assessment.
Purpose of the Study:
- To evaluate the efficacy of quantitative MRI signal analysis in predicting stroke-to-MRI delay.
- To compare the performance of quantitative MRI signal analysis against the visual estimation of DWI-FLAIR mismatch.
Main Methods:
- Retrospective analysis of 194 ischemic stroke patients (middle cerebral artery territory) within 12 hours of 3T MRI.
- Visual estimation of DWI-FLAIR mismatch by two radiologists.
- Manual segmentation for quantitative MRI signal analysis (DWI and FLAIR).
Main Results:
- Quantitative variables including B0, B1000, and apparent diffusion coefficient (ADC) values were predictive of stroke-to-MRI delay.
- FLAIR signal quantification was not found to be predictive.
- The relative B1000 value showed the best predictive performance among quantitative measures, comparable to visual classification.
Conclusions:
- Quantitative MRI signal analysis can be a useful adjunct for estimating stroke onset.
- Visual estimation of DWI-FLAIR mismatch currently remains superior to quantitative methods for stroke age determination.
