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Comparative Activities of Cattle and Swine Platelet Microbicidal Proteins

Iuri B Ivanov1, Viktor A Gritsenko2

  • 1Department of Human Microbiology, Institute of Cellular and Intracellular Symbiosis, Russian Academy of Sciences, Volgogradskaya St., 36/3, of.93, Orenburg, 460056, Russia. mil-for@rambler.ru.

Probiotics and Antimicrobial Proteins
|January 20, 2016
PubMed

Insights

Cattle and swine platelet microbicidal proteins (PMPs) exhibit potent bactericidal activity against various bacteria, including Bacillus species and Staphylococcus aureus. This study confirms the conserved presence of these antimicrobial peptides across mammalian platelets.

Area of Science:

  • Microbiology
  • Immunology
  • Biochemistry

Background:

  • Platelet microbicidal proteins (PMPs) are crucial antimicrobial components found in platelets.
  • Understanding the spectrum of PMP activity is vital for developing novel antimicrobial strategies.

Purpose of the Study:

  • To investigate and compare the bactericidal activities of cattle and swine PMPs against a panel of bacteria.
  • To compare these activities with human PMPs.

Main Methods:

  • Bactericidal activity assays were performed using PMPs from cattle and swine.
  • The PMPs were tested against Gram-positive bacteria (Bacillus subtilis, Bacillus cereus, Staphylococcus aureus, Staphylococcus epidermidis, Micrococcus lysodeikticus) and a Gram-negative bacterium (Escherichia coli).

Main Results:

  • B. subtilis and B. cereus showed high susceptibility to PMPs even at low concentrations.
  • Among Gram-positive cocci, M. lysodeikticus and S. aureus were most susceptible, while S. epidermidis was least susceptible.
  • Escherichia coli demonstrated relative resistance to the bactericidal effects of all tested PMPs.

Conclusions:

  • Mammalian platelets conserve antimicrobial peptides with broad-spectrum bactericidal properties.
  • Cattle and swine PMPs display significant antimicrobial activity, comparable to human PMPs, highlighting their potential therapeutic applications.
Keywords:
CowPlatelet microbicidal proteinSwine

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