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Toxocara canis: Larvicidal activity of fatty acid amides
Taís Mata-Santos1, Caroline da Ros Montes D'Oca2, Hílton Antônio Mata-Santos3
1Parasitology Laboratory, Faculty of Medicine, Universidade Federal do Rio Grande, Rio Grande, Brazil.
Abstract:
Considering the therapeutic potential of fatty acid amides, the present study aimed to evaluate their in vitro activity against Toxocara canis larvae and their cytotoxicity for the first time. Linoleylpyrrolidilamide was the most potent, with a minimal larvicidal concentration (MLC) of 0.05 mg/mL and 27% cytotoxicity against murine peritoneal macrophages C57BL/6 mice, as assessed by the MTT assay.
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